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Article

Mode of action and mechanisms of resistance for antimalarial drugs.

Pharmacology & therapeutics - 1 Feb 2001

Olliaro P

Abstract excerpt

Understanding the mode of action of and mechanism of resistance to drugs is central to optimising their use, and discovering new therapeutics with novel targets. We have limited understanding of how antimalarial drugs work and how resistance emerges. With few exceptions, antimalarial drugs in current use belong to a limited collection of chemical structures that act on a small number of partially characterised...

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PMID: 11316521
DOI: 10.1016/s0163-7258(00)00115-7

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