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Article

Comparison of the aneugenic effect of vinorelbine and vincristine in cultured human lymphocytes

1 Jan 1999

Abstract excerpt

Vinca alkaloids are used clinically against a variety of hematological and solid tumors. These compounds interact with tubulin subunits to prevent microtubule assembly, inducing abnormal chromosome segregation in dividing cells and causing aneuploidy. The vinca alkaloid vincristine sulfate (VCR) and the semisynthetic analog vinorelbine (VRB) were studied by analysis of micronuclei (MN) in cultured human...

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Identifiers

PMID: 10474823
DOI: 10.1093/mutage/14.1.63

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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