Article
Cigarette smoking drives earlier development of pancreatic adenocarcinoma among carriers of hereditary pancreatic cancer susceptibility genes.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Aug 2026
Shu Timothy D, Smith Lynette M, Gunnarsson Erik, Paniccia Alessandro, Lee Kenneth K, Dudley Beth, Karloski Eve, Worthington Christine, Singhi Aatur D, Zureikat Amer, Brand Randall E
Abstract excerpt
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) surveillance is recommended for high-risk individuals (HRI) carrying pathogenic variants (PV) in PDAC susceptibility genes or meeting criteria for familial pancreatic cancer (FPC). Cigarette smoking drives earlier PDAC onset in general populations, but this effect is not well-characterized among HRIs. We hypothesized that smoking accelerates the age at PDAC...
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