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Article

Converting an esterase into an epoxide hydrolase.

Angewandte Chemie (International ed. in English) - 1 Jan 2009

Jochens Helge, Stiba Konstanze, Savile Christopher, Fujii Ryota, Yu Juin-Guo, Gerassenkov Tatsiana, Kazlauskas Romas J, Bornscheuer Uwe T

Abstract excerpt

Entering the fold: A common structural motif in hydrolytic enzymes is the alpha,beta-hydrolase fold. The interconversion of one enzyme into another by introduction of mechanistically important residues is not enough; only substitution of a loop allows epoxide hydrolase activity in the esterase scaffold to be formed (see picture; structure comparison of epoxide hydrolases (green) with the esterase (orange)). The...

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Identifiers

PMID: 19350592
DOI: 10.1002/anie.200806276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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