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Article

Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux.

Pediatric nephrology (Berlin, Germany) - 1 Aug 2009

Zu Shulu, Bartik Zsuzsa, Zhao Shengtian, Sillen Ulla, Nordenskjöld Agneta

Abstract excerpt

Familial clustering of vesico-ureteral reflux (VUR) suggests that genetic factors play an important role in the pathogenesis of this condition. The SLIT2 protein and its receptor, ROBO2, have key functions in the formation of the ureteric bud. Two recent studies have found that ROBO2 gene missense mutations are associated with VUR. In the study reported here, we investigated the genetic contribution of the SLIT2...

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Source

Identifiers

PMID: 19350278
DOI: 10.1007/s00467-009-1179-9

Genes

ROBO2
SLIT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux.PMID 19350278Read ↗

ROBO2 gene variants are associated with familial vesicoureteral reflux.Semantic proximity Read ↗

Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.Semantic proximity Read ↗

Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux.Semantic proximity Read ↗

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Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral RefluxSemantic proximity Read ↗

Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.Semantic proximity Read ↗

Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.Semantic proximity Read ↗

Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.Semantic proximity Read ↗

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