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Article

Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux.

Kidney international - 1 Aug 2013

Dobson Mark G, Darlow John M, Hunziker Manuela, Green Andrew J, Barton David E, Puri Prem

Abstract excerpt

ROBO2, the receptor of SLIT2, is one of many genes/proteins that regulate the outgrowth of the ureteric bud, which is the first step in the development of the metanephric urinary system. Non-synonymous variants in ROBO2 have been found in a small proportion of patients with primary vesicoureteric reflux (VUR) in various countries. Here we sequenced 1 kb of promoter and all exons of ROBO2b with intronic margins in...

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Source

Identifiers

PMID: 23536131
DOI: 10.1038/ki.2013.100

Genes

ROBO2
SLIT2

Variants

Provenance

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Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux.PMID 23536131Read ↗

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