Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

doi:10.1086/512735

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Article

Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

American journal of human genetics - 1 Apr 2007

Lu Weining, van Eerde Albertien M, Fan Xueping, Quintero-Rivera Fabiola, Kulkarni Shashikant, Ferguson Heather, Kim Hyung-Goo, Fan Yanli, Xi Qiongchao, Li Qing-Gang, Sanlaville Damien, Andrews William, Sundaresan Vasi, Bi Weimin, Yan Jiong, Giltay Jacques C, Wijmenga Cisca, de Jong Tom P V M, Feather Sally A, Woolf Adrian S, Rao Yi, Lupski James R, Eccles Michael R, Quade Bradley J, Gusella James F, Morton Cynthia C, Maas Richard L

Abstract excerpt

Congenital anomalies of the kidney and urinary tract (CAKUT) include vesicoureteral reflux (VUR). VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults. We investigated a man with a de novo translocation,...

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Identifiers

PMID: 17357069
DOI: 10.1086/512735
PMCID: PMC1852714

Genes

ROBO2

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.PMID 17357069Read ↗

ROBO2 gene variants are associated with familial vesicoureteral reflux.Semantic proximity Read ↗

Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux.Semantic proximity Read ↗

Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.Semantic proximity Read ↗

Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.Semantic proximity Read ↗

Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral RefluxSemantic proximity Read ↗

Molecular causes of congenital anomalies of the kidney and urinary tract (CAKUT)Semantic proximity Read ↗

ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia.Semantic proximity Read ↗

Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary TractSemantic proximity Read ↗

Congenital anomalies of the kidney and urinary tractSemantic proximity Read ↗

Responsible genes in children with primary vesicoureteral reflux: findings from the Chinese Children Genetic Kidney Disease Database.Semantic proximity Read ↗

TNXB mutations can cause vesicoureteral reflux.Semantic proximity Read ↗

Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.Semantic proximity Read ↗

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