Article
Genes in the ureteric budding pathway: association study on vesico-ureteral reflux patients.
PloS one - 1 Jan 2012
van Eerde Albertien M, Duran Karen, van Riel Els, de Kovel Carolien G F, Koeleman Bobby P C, Knoers Nine V A M, Renkema Kirsten Y, van der Horst Henricus J R, Bökenkamp Arend, van Hagen Johanna M, van den Berg Leonard H, Wolffenbuttel Katja P, van den Hoek Joop, Feitz Wouter F, de Jong Tom P V M, Giltay Jacques C, Wijmenga Cisca
Abstract excerpt
Vesico-ureteral reflux (VUR) is the retrograde passage of urine from the bladder to the urinary tract and causes 8.5% of end-stage renal disease in children. It is a complex genetic developmental disorder, in which ectopic embryonal ureteric budding is implicated in the pathogenesis. VUR is part of the spectrum of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). We performed an extensive association...
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