Article
Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.
Journal of the American Society of Nephrology : JASN - 1 Jan 2010
Cordell Heather J, Darlay Rebecca, Charoen Pimphen, Stewart Aisling, Gullett Ambrose M, Lambert Heather J, Malcolm Sue, Feather Sally A, Goodship Timothy H J, Woolf Adrian S, Kenda Rajko B, Goodship Judith A
Abstract excerpt
Primary vesicoureteric reflux accounts for approximately 10% of kidney failure requiring dialysis or transplantation, and sibling studies suggest a large genetic component. Here, we report a whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux and reflux nephropathy. We used linkage and family-based association approaches to analyze 320 white families (661 affected individuals,...
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