Article
Evaluation of glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2009
Yang Ping, Mandrekar Sumithra J, Hillman Shauna H, Allen Ziegler Katie L, Sun Zhifu, Wampfler Jason A, Cunningham Julie M, Sloan Jeff A, Adjei Alex A, Perez Edith, Jett James R
Abstract excerpt
INTRODUCTION: We evaluated the role of glutathione-related genotypes on overall survival, time to progression, adverse events, and quality of life (QOL) in stage IIIB/IV non-small cell lung cancer patients who were stable or responding from initial treatment with platinum-based chemotherapy and subsequently randomized to receive daily oral carboxyaminoimidazole or a placebo. METHODS: Of the 186 total patients,...
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