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Article

Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients.

Swiss medical weekly - 1 Jan 2011

Zhou Fei, Yu Zhuang, Jiang Tao, Lv Hongying, Yao Ruyong, Liang Jun

Abstract excerpt

PRINCIPLES: Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical outcome in NSCLC patients treated with platinum-based regimens. METHODS: We used DNA sequencing methods to evaluate genetic polymorphisms of the GSTP1A313G and...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glutathione S-Transferase pi

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Source

Identifiers

PMID: 22009704
DOI: 10.4414/smw.2011.13275

Genes

GSTP1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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