Article
glial cells missing: a genetic switch that controls glial versus neuronal fate.
Cell - 22 Sept 1995
Jones B W, Fetter R D, Tear G, Goodman C S
Abstract excerpt
The glial cells missing (gcm) gene in Drosophila encodes a novel nuclear protein that is transiently expressed early in the development of nearly all glia. In loss-of-function gcm mutant alleles, nearly all glia fail to differentiate, and, where we can follow them in the PNS, are transformed into neurons. In gain-if-function gcm conditions using transgenic constructs that drive ectopic gcm expression, many...
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