Article
glial cells missing: a genetic switch that controls glial versus neuronal fate.
Cell - 22 Sept 1995
Jones B W, Fetter R D, Tear G, Goodman C S
Abstract excerpt
The glial cells missing (gcm) gene in Drosophila encodes a novel nuclear protein that is transiently expressed early in the development of nearly all glia. In loss-of-function gcm mutant alleles, nearly all glia fail to differentiate, and, where we can follow them in the PNS, are transformed into...
Topics
- Amino Acid Sequence
- Animals
- Cell Differentiation
- Central Nervous System
- Cloning, Molecular
- Drosophila
- Gene Expression Regulation, Developmental
- Genes, Insect
- Molecular Sequence Data
- Mutation
- Neuroglia
- Neurons
- Nuclear Proteins
- Peripheral Nervous System