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Article

Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density.

Diagnostic microbiology and infectious disease - 1 Jun 2009

Tsuji Brian T, Harigaya Yoriko, Lesse Alan J, Sakoulas George, Mylotte Joseph M

Abstract excerpt

The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

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Identifiers

PMID: 19345040
DOI: 10.1016/j.diagmicrobio.2009.01.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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