miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

Abstract excerpt

UNLABELLED: MicroRNAs play a crucial role in the regulation of cell growth and differentiation. Mice with genetic deletion of miR-375 exhibit impaired glycemic control due to decreased β-cell and increased α-cell mass and function. The relative importance of these processes for the overall phenotype of miR-375KO mice is unknown. Here, we show that mice overexpressing miR-375 exhibit normal β-cell mass and...

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