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Article

Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.

PloS one - 1 Jan 2012

Marin Marioara B, Ghenea Simona, Spiridon Laurentiu N, Chiritoiu Gabriela N, Petrescu Andrei-Jose, Petrescu Stefana-Maria

Abstract excerpt

EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing of tyrosinase, a tumour antigen overexpressed in melanoma cells. First, we analyzed and modeled EDEM1 major domains. The homology model raised on the crystal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22905195
DOI: 10.1371/journal.pone.0042998
PMCID: PMC3414498

Genes

EDEM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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