Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2022

Wang Bo, Tian Debin, Sooryanarain Harini, Mahsoub Hassan M, Heffron C Lynn, Hassebroek Anna M, Meng Xiang-Jin

Abstract excerpt

Hepatitis E virus (HEV) infection in pregnant women has a high incidence of developing fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in genotype 1 HEV (HEV-1) are reportedly linked to FHF clinical cases, but experimental confirmation of the roles of these changes in FHF is lacking. By utilizing the HEV-1 indicator replicon and infectious clone, we generated 11 HEV-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genotype
Share to Hepatitis E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis E virus

Share to Liver Failure, Acute

Share to Mutation

Share to Pregnancy

Share to Ribavirin

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 35969750
DOI: 10.1073/pnas.2207503119
PMCID: PMC9407470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure.PMID 35969750Read ↗

Hepatitis E Virus Mutations: Functional and Clinical Relevance.Semantic proximity Read ↗

The hepatitis E virus nonstructural polyprotein.Semantic proximity Read ↗

Hepatitis E Virus ReplicationSemantic proximity Read ↗

Hepatitis E virus RNA-dependent RNA polymerase is involved in RNA replication and infectious particle production.Semantic proximity Read ↗

A tightly clustered hepatitis E virus genotype 1a is associated with endemic and outbreak infections in Bangladesh.Semantic proximity Read ↗

Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication.Semantic proximity Read ↗

Hepatitis E virus genotype 1f outbreak in Bangladesh, 2018.Semantic proximity Read ↗

Open Reading Frame 4 Is Not Essential in the Replication and Infection of Genotype 1 Hepatitis E Virus.Semantic proximity Read ↗

Mutational Analysis of the Hypervariable Region of Hepatitis E Virus Reveals Its Involvement in the Efficiency of Viral RNA ReplicationSemantic proximity Read ↗

Report of a novel C1483W mutation in the hepatitis E virus polymerase in patients with acute liver failure.Semantic proximity Read ↗

Nucleotide substitutions of hepatitis E virus genomes associated with fulminant hepatitis and disease severity.Semantic proximity Read ↗

Three Amino Acid Mutations (F51L, T59A, and S390L) in the Capsid Protein of the Hepatitis E Virus Collectively Contribute to Virus AttenuationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.