Article
HLA-DR4, DR13(6) and the ancestral haplotype A1B8DR3 are associated with ANCA-associated vasculitis and Wegener's granulomatosis.
Rheumatology (Oxford, England) - 1 Jun 2009
Stassen Patricia M, Cohen-Tervaert Jan W, Lems Simon P M, Hepkema Bouke G, Kallenberg Cees G M, Stegeman Coen A
Abstract excerpt
OBJECTIVES: As the HLA system is involved in recognition of self and non-self, an association with the development of ANCA-associated vasculitis (AAV) seems probable. In this study, the relation between HLA antigens and AAV and it's severity were investigated. METHODS: Consecutive patients diagnosed with AAV at our centre, who were followed for at least 2 years, were included. The frequency of HLA antigens of AAV...
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