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Article

Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.

The Journal of biological chemistry - 5 Jun 2009

Jia Juan, Maccarana Marco, Zhang Xiao, Bespalov Maxim, Lindahl Ulf, Li Jin-Ping

Abstract excerpt

HSEPI (glucuronyl C5-epimerase) catalyzes the conversion of d-glucuronic acid to l-iduronic acid in heparan sulfate (HS) biosynthesis. Disruption of the Hsepi gene in mice yielded a lethal phenotype with selective organ defects but had remarkably little effect on other organ systems. We have approached the underlying mechanisms by examining the course and effects of FGF2 signaling in a mouse embryonic fibroblast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fibroblast Growth Factor 2

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Source

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Identifiers

PMID: 19336402
DOI: 10.1074/jbc.M809577200
PMCID: PMC2708889

Genes

FGF2
FGF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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