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Article

Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.

Developmental cell - 16 Aug 2011

Shimokawa Kayo, Kimura-Yoshida Chiharu, Nagai Naoko, Mukai Kazuhiro, Matsubara Kazumi, Watanabe Hideto, Matsuda Yoichi, Mochida Kyoko, Matsuo Isao

Abstract excerpt

Heparan sulfate (HS) proteoglycans modulate the activity of multiple growth factors on the cell surface and extracellular matrix. However, it remains unclear how the HS chains control the movement and reception of growth factors into targeted receiving cells during mammalian morphogenetic processes. Here, we found that HS-deficient Ext2 null mutant mouse embryos fail to respond to fibroblast growth factor (FGF)...

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Source

Identifiers

PMID: 21839920
DOI: 10.1016/j.devcel.2011.06.027

Genes

FGF4
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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