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Article

Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells

30 Mar 2009

Abstract excerpt

Differentiation of prevalvular mesenchyme into valve fibroblasts is an integral step towards the development of functionally mature cardiac valves. Although clinically relevant, little is known regarding the molecular and cellular mechanisms by which this process proceeds. Genes that are regulated in a spatio-temporal pattern during valve remodeling are candidates for affecting this differentiation process. Based...

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Share to Cardiac Fibrosis and Remodeling
Share to Cardiac Structural Anomalies and Repair
Share to Cardiac Valve Diseases and Treatments

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PMID: 19334280
DOI: 10.1002/dvdy.21933

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