Article
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen.
Blood - 2 Jul 2009
ter Brugge Petra J, Ta Van B T, de Bruijn Marjolein J W, Keijzers Guido, Maas Alex, van Gent Dik C, Hendriks Rudi W
Abstract excerpt
The simian virus 40 (SV40) T antigen is a potent oncogene able to transform many cell types and has been implicated in leukemia and lymphoma. In this report, we have achieved sporadic SV40 T-antigen expression in mature B cells in mice, by insertion of a SV40 T antigen gene in opposite transcriptional orientation in the immunoglobulin (Ig) heavy (H) chain locus between the D and J(H) segments. SV40 T-antigen...
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