Article
Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation.
Molecular cancer - 3 May 2005
Rosty Christophe, Aubriot Marie-Hélène, Cappellen David, Bourdin Jérôme, Cartier Isabelle, Thiery Jean Paul, Sastre-Garau Xavier, Radvanyi François
Abstract excerpt
BACKGROUND: We have previously reported activating mutations of the gene coding for the fibroblast growth factor receptor 3 (FGFR3) in invasive cervical carcinoma. To further analyze the role of FGFR3 in cervical tumor progression, we extended our study to screen a total of 75 invasive tumors and 80 cervical intraepithelial neoplasias (40 low-grade and 40 high-grade lesions). RESULTS: Using single strand...
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