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Phosphosite Analysis of the Cytomegaloviral mRNA Export Factor pUL69 Reveals Serines with Critical Importance for Recruitment of Cellular Proteins Pin1 and UAP56/URH49.

Journal of virology - 31 Mar 2020

Thomas Marco, Müller Regina, Horn Georg, Bogdanow Boris, Imami Koshi, Milbradt Jens, Steingruber Mirjam, Marschall Manfred, Schilling Eva-Maria, Fossen Torgils, Stamminger Thomas

Abstract excerpt

Human cytomegalovirus (HCMV) encodes the viral mRNA export factor pUL69, which facilitates the cytoplasmic accumulation of mRNA via interaction with the cellular RNA helicase UAP56 or URH49. We reported previously that pUL69 is phosphorylated by cellular CDKs and the viral CDK-like kinase pUL97. Here, we set out to identify phosphorylation sites within pUL69 and to characterize their importance. Mass...

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Identifiers

PMID: 31969433
DOI: 10.1128/JVI.02151-19
PMCID: PMC7108844

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