Article
ParkScreen: a low-cost rapid linkage marker panel for Parkinson's disease.
Journal of molecular neuroscience : MN - 1 Sept 2009
De Grandi Alessandro, Volpato Claudia Béu, Bedin Elisa, Pattaro Cristian, Marroni Fabio, Pichler Irene, Hicks Andrew Antony, Casari Giorgio, Pramstaller Peter Paul
Abstract excerpt
A genetic marker screening panel, ParkScreen, optimized for simultaneous marker amplification, was constructed to test or exclude linkage in families with parkinsonism or Parkinson's disease, using only a few affected individuals per family. ParkScreen functionality was proven by detection of linkage to PARK2 in a family with known Parkin mutations, exclusion of linkage to several of the known loci, and detection...
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