Article
Construction and validation of a Parkinson's disease mutation genotyping array for the Parkin gene.
Movement disorders : official journal of the Movement Disorder Society - 15 May 2007
Clark Lorraine N, Haamer Eneli, Mejia-Santana Helen, Harris Juliette, Lesage Suzanne, Durr Alexandra, Bs Sabine Janin, Hedrich Katja, Louis Elan D, Cote Lucien J, Andrews Howard, Fahn Stanley, Waters Cheryl, Ford Blair, Frucht Steven, Scott William, Klein Christine, Brice Alexis, Roomere Hanno, Ottman Ruth, Marder Karen
Abstract excerpt
Parkin mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the Parkin gene that includes homozygous, compound heterozygous, and single heterozygous mutations. We have designed a Parkin mutation genotyping array (gene chip) that includes published Parkin sequence variants and allows...
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