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Article

c-Met is a potentially new therapeutic target for treatment of human melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2007

Puri Neelu, Ahmed Salman, Janamanchi Varalakshmi, Tretiakova Maria, Zumba Osvaldo, Krausz Thomas, Jagadeeswaran Ramasamy, Salgia Ravi

Abstract excerpt

PURPOSE: c-Met is a receptor tyrosine kinase involved in cell growth, invasion, metastases, and angiogenesis. In this study, we investigated the role of c-Met in melanoma biology using a novel small-molecule tyrosine kinase inhibitor SU11274 and small interfering (si) RNA against the receptor. EXPERIMENTAL DESIGN: The effects of SU11274 and c-Met siRNA were studied on proliferation, apoptosis, differentiation,...

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Identifiers

PMID: 17404109
DOI: 10.1158/1078-0432.CCR-06-0776

Genes

MITF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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