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Article

Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype.

Cancer research - 1 Apr 2009

Balliet Renee M, Chen Gang, Gallagher Carla J, Dellinger Ryan W, Sun Dongxiao, Lazarus Philip

Abstract excerpt

Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor used in the treatment of cutaneous T-cell lymphoma and in clinical trials for treatment of multiple other cancers. A major mode of SAHA metabolism is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes. To characterize the UGTs active against SAHA, homogenates from HEK293 cell lines overexpressing UGT wild-type or...

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Identifiers

PMID: 19318555
DOI: 10.1158/0008-5472.CAN-08-4143
PMCID: PMC2694132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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