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Article

Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

PloS one - 1 Jan 2013

Wang Ling-Zhi, Ramírez Jacqueline, Yeo Winnie, Chan Mei-Yi Michelle, Thuya Win-Lwin, Lau Jie-Ying Amelia, Wan Seow-Ching, Wong Andrea Li-Ann, Zee Ying-Kiat, Lim Robert, Lee Soo-Chin, Ho Paul C, Lee How-Sung, Chan Anthony, Ansher Sherry, Ratain Mark J, Goh Boon-Cher

Abstract excerpt

UNLABELLED: Belinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies. We studied the pharmacokinetics of belinostat in hepatocellular carcinoma patients to determine the main pa...

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Source

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Identifiers

PMID: 23382909
DOI: 10.1371/journal.pone.0054522
PMCID: PMC3559838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23382909-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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