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Article

Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

PloS one - 1 Jan 2013

Wang Ling-Zhi, Ramírez Jacqueline, Yeo Winnie, Chan Mei-Yi Michelle, Thuya Win-Lwin, Lau Jie-Ying Amelia, Wan Seow-Ching, Wong Andrea Li-Ann, Zee Ying-Kiat, Lim Robert, Lee Soo-Chin, Ho Paul C, Lee How-Sung, Chan Anthony, Ansher Sherry, Ratain Mark J, Goh Boon-Cher

Abstract excerpt

UNLABELLED: Belinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies. We studied the pharmacokinetics of belinostat in hepatocellular carcinoma patients to determine the main pathway of metabolism of belinostat. The pharmacokinetics of belinostat in liver cancer patients were characterized by...

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Identifiers

PMID: 23382909
DOI: 10.1371/journal.pone.0054522
PMCID: PMC3559838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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