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Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer.

Pharmacogenetics and genomics - 1 Nov 2011

Wong Nan-Soon, Seah Elaine Zh, Wang Ling-Zhi, Yeo Wee-Lee, Yap Hui-Ling, Chuah Benjamin, Lim Yi-Wan, Ang Peter Cs, Tai Bee-Choo, Lim Robert, Goh Boon-Cher, Lee Soo-Chin

Abstract excerpt

OBJECTIVES: Vorinostat, a histone deacetylase inhibitor being actively evaluated in solid tumors, is metabolized by UGT2B17. UGT2B17 null genotype (UGT2B17*2) has been shown in vitro to reduce UGT2B17 activity. This variant is common in Asians but rare in Caucasians, and we studied its impact on vorinostat pharmacokinetics and pharmacodynamics in a clinical study in Asian patients with metastatic breast cancer....

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PMID: 21849928
DOI: 10.1097/FPC.0b013e32834a8639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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