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Article

The number of octapeptide repeat affects the expression and conversion of prion protein.

Biochemical and biophysical research communications - 15 May 2009

Hiraga Chihiro, Kobayashi Atsushi, Kitamoto Tetsuyuki

Abstract excerpt

The human prion protein (PrP) has five copies of an octapeptide repeat (OR). The mutant PrP with 6-14 OR causes the genetic form of Creutzfeldt-Jakob disease (CJD). To determine the influence of OR on the conversion of PrP, we examined the conversion efficiency of mouse mutant PrP molecules with 1-16 OR in scrapie-infected cells. The expression level of mutant PrP and the glycoform ratio of the abnormal isoform...

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Source

Identifiers

PMID: 19318088
DOI: 10.1016/j.bbrc.2009.03.093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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