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Article

Instability of the octarepeat region of the human prion protein gene.

PloS one - 1 Jan 2011

Li Baiya, Qing Liuting, Yan Jianqun, Kong Qingzhong

Abstract excerpt

Prion diseases are a family of unique fatal transmissible neurodegenerative diseases that affect humans and many animals. Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common prion disease in humans, accounting for 85-90% of all human prion cases, and exhibits a high degree of diversity in phenotypes. The etiology of sCJD remains to be elucidated. The human prion protein gene has an octapeptide repeat...

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Identifiers

PMID: 22028931
DOI: 10.1371/journal.pone.0026635
PMCID: PMC3197570

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Source receipt: pubmed, retrieved 7 Sept 2026.

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