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Article

Aggregation of prion protein with insertion mutations is proportional to the number of inserts.

The Biochemical journal - 15 Apr 2007

Yu Shuiliang, Yin Shaoman, Li Chaoyang, Wong Poki, Chang Binggong, Xiao Fan, Kang Shin-Chung, Yan Huimin, Xiao Gengfu, Tien Po, Sy Man-Sun

Abstract excerpt

Mutation in the prion gene, PRNP, accounts for approx. 10-15% of human prion diseases. However, little is known about the mechanisms by which a mutant prion protein (PrP) causes disease. We compared the biochemical properties of a wild-type human prion protein, rPrP(C) (recombinant wild-type PrP), which has five octapeptide-repeats, with two recombinant human prion proteins with insertion mutations, one with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17187581
DOI: 10.1042/BJ20061592
PMCID: PMC1874237

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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