Article
Posttranslational modifications within the HIV-1 envelope glycoprotein which restrict virus assembly and CD4-dependent infection.
AIDS research and human retroviruses - 1 Jun 1991
Haggerty S, Dempsey M P, Bukrinsky M I, Guo L, Stevenson M
Abstract excerpt
Alterations in two highly conserved N-linked glycosylation sites within the gp120 envelope glycoprotein of human immunodeficiency virus type I (HIV-1) implicated in the phenotype of a noncytopathic HIV-1 variant were introduced independently and in combination into a cytopathic, infectious HIV-1 clone by site-specific mutagenesis. Neither mutation affected the synthesis of HIV-1 envelope glycoproteins. However,...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- CD4 Antigens
- Cell Membrane
- Cells, Cultured
- DNA, Viral
- Gene Products, env
- Glycosylation
- HIV Envelope Protein gp120
- HIV Seropositivity