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Article

Posttranslational modifications within the HIV-1 envelope glycoprotein which restrict virus assembly and CD4-dependent infection.

AIDS research and human retroviruses - 1 Jun 1991

Haggerty S, Dempsey M P, Bukrinsky M I, Guo L, Stevenson M

Abstract excerpt

Alterations in two highly conserved N-linked glycosylation sites within the gp120 envelope glycoprotein of human immunodeficiency virus type I (HIV-1) implicated in the phenotype of a noncytopathic HIV-1 variant were introduced independently and in combination into a cytopathic, infectious HIV-1 clone by site-specific mutagenesis. Neither mutation affected the synthesis of HIV-1 envelope glycoproteins. However,...

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Identifiers

PMID: 1931229
DOI: 10.1089/aid.1991.7.501
PMCID: PMC9507334

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