Article
HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments.
Virology journal - 23 Jan 2008
Ho Yung Shwen, Abecasis Ana B, Theys Kristof, Deforche Koen, Dwyer Dominic E, Charleston Michael, Vandamme Anne Mieke, Saksena Nitin K
Abstract excerpt
BACKGROUND: N-linked glycosylation is a major mechanism for minimizing virus neutralizing antibody response and is present on the Human Immunodeficiency Virus (HIV) envelope glycoprotein. Although it is known that glycosylation changes can dramatically influence virus recognition by the host antibody, the actual contribution of compartmental differences in N-linked glycosylation patterns remains unclear....
Topics
- Amino Acids
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Bayes Theorem
- Genetic Variation
- Glycosylation
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Leukocytes
- Monocytes
- Phylogeny
- Plasma