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Article

Colorectal cancer risks in relatives of young-onset cases: is risk the same across all first-degree relatives?

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Oct 2007

Boardman Lisa A, Morlan Bruce W, Rabe Kari G, Petersen Gloria M, Lindor Noralane M, Nigon Sandra K, Goldberg Julia, Gallinger Steven

Abstract excerpt

BACKGROUND & AIMS: During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one...

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Identifiers

PMID: 17702662
DOI: 10.1016/j.cgh.2007.06.001
PMCID: PMC2180165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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