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Article

Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary.

Developmental biology - 1 Jun 2009

Epstein Andrew M, Bauer Christopher R, Ho Aaron, Bosco Giovanni, Zarnescu Daniela C

Abstract excerpt

FMRP is an RNA binding protein linked to the most common form of inherited mental retardation, Fragile X syndrome (FraX). In addition to severe cognitive deficits, FraX etiology includes postpubescent macroorchidism, which is thought to result from overproliferation. Using a Drosophila FraX model, we show that FMRP controls germline proliferation during oogenesis. dFmr1 null ovaries contain egg chambers with both...

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Identifiers

PMID: 19306863
DOI: 10.1016/j.ydbio.2009.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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