Article
Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice.
Human molecular genetics - 1 Dec 2012
Lu Cuiling, Lin Li, Tan Huiping, Wu Hao, Sherman Stephanie L, Gao Fei, Jin Peng, Chen Dahua
Abstract excerpt
Spontaneous 46,XX primary ovarian insufficiency (POI), also known as 'premature menopause' or 'premature ovarian failure', refers to ovarian dysfunction that results in a range of abnormalities, from infertility to early menopause as the end stage. The most common known genetic cause of POI is the expansion of a CGG repeat to 55-199 copies (premutation) in the 5' untranslated region in the X-linked fragile X...
Topics
- 5' Untranslated Regions
- Alleles
- Animals
- Apoptosis
- Disease Models, Animal
- Female
- Fertility
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Gonadal Hormones
- Humans
- Mice
- Mice, Transgenic
- Ovarian Follicle