Article
Daptomycin pharmacodynamics against Staphylococcus aureus hemB mutants displaying the small colony variant phenotype.
The Journal of antimicrobial chemotherapy - 1 May 2009
Begic Damir, von Eiff Christof, Tsuji Brian T
Abstract excerpt
OBJECTIVES: Staphylococcus aureus small colony variants (SCVs) are slow-growing morphological variants associated with persistent infections. While vancomycin activity has been shown to be attenuated against SCVs of S. aureus, few data exist regarding daptomycin. The objective was to evaluate the pharmacodynamics of daptomycin against defined S. aureus mutants displaying the SCV phenotype. METHODS: Two S. aureus...
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