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Article

Allosteric effect of amphiphile binding to phospholipase A(2).

Biochemistry - 14 Apr 2009

Yu Bao-Zhu, Bai Shi, Berg Otto G, Jain Mahendra K

Abstract excerpt

In the preceding paper, we showed that the formation of the second premicellar complex of pig pancreatic IB phospholipase A2 (PLA2) can be considered a proxy for interface-activated substrate binding. Here we show that this conclusion is supported by results from premicellar E(i)(#) (i = 1, 2, or 3) complexes with a wide range of mutants of PLA2. Results also show a structural basis for the correlated functional...

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Identifiers

PMID: 19301848
DOI: 10.1021/bi801245s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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