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Article

Genome-Wide Association Studies: What Do They Teach Us about Asthma and Chronic Obstructive Pulmonary Disease?

1 Dec 2009

Abstract excerpt

Genome-wide association (GWA) studies are applied to identify novel genetic variants that are associated with disease. Results of the first three GWA studies on asthma identified susceptibility genes for asthma as ORMDL3, IL1RL1, and PDE4D. The first GWA study on chronic obstructive pulmonary disease (COPD) identified two single nucleotide polymorphisms at the alpha-nicotinic acetylcholine receptor (CHRNA 3/5)...

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PMID: 20008879
DOI: 10.1513/pats.200907-058dp

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