Human TRIM Gene Expression in Response to Interferons

Abstract excerpt

BACKGROUND: Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity. PRINCIPAL FINDINGS: To test if TRIM genes are up-regulated during antiviral immune responses, we...

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