Article
Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers.
European journal of nutrition - 1 Aug 2009
Galván-Portillo Marcia V, Cantoral Alejandra, Oñate-Ocaña Luis F, Chen Jia, Herrera-Goepfert Roberto, Torres-Sanchez Luisa, Hernandez-Ramirez Raul U, Palma-Coca Oswaldo, López-Carrillo Lizbeth
Abstract excerpt
BACKGROUND: DNA methylation is an important epigenetic process for transcriptional control of human genome including those genes involved in cancer initiation and progression. Clinical studies have suggested that biological explanation to the protective effect of some nutrients could be linked with the DNA methylation. Folate is a primary methyl donor nutrient; it has been shown to play a key role in DNA...
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