Article
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
Journal of bacteriology - 1 May 2009
Kim Ji-Yun, Inaoka Takashi, Hirooka Kazutaka, Matsuoka Hiroshi, Murata Makiko, Ohki Reiko, Adachi Yoshikazu, Fujita Yasutaro, Ochi Kozo
Abstract excerpt
Using comparative genome sequencing analysis, we identified a novel mutation in Bacillus subtilis that confers a low level of resistance to fusidic acid. This mutation was located in the mdtR (formerly yusO) gene, which encodes a MarR-type transcriptional regulator, and conferred a low level of resistance to several antibiotics, including novobiocin, streptomycin, and actinomycin D. Transformation experiments...
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