Article

Mapping the Constrained Coding Regions in the human genome to their corresponding proteins

2022-09-14

Abstract excerpt

<h4>ABSTRACT</h4> Constrained Coding Regions (CCRs) in the human genome have been derived from DNA sequencing data of large cohorts of healthy control populations, available in the Genome Aggregation Database (gnomAD) [1]. They identify regions depleted of protein-changing variants and thus identify segments of the genome that have been constrained during human evolution. By mapping these DNA-defined regions from...

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Literature Corpus work: 5828472e-acf8-5c4e-b6e1-a6a8b01b210d
DOI: 10.1101/2022.09.12.507545

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