Article
[K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer].
Vojnosanitetski pregled - 1 Feb 2009
Cvetković Gordana, Plavec Goran, Tomić Ilija, Ilić Vesna, Magić Zvonko, Tatomirović Zeljka, Novković Dobrivoje, Milić Rade, Karlicić Vukojica
Abstract excerpt
BACKGROUND/AIM: K-ras oncogene is mutated in about 20% of lung cancer. The purpose of this study was to investigate the predictive significance for therapeutic response of K-ras mutations in advanced non-small cell lung cancer (NSCLC) patients. METHODS: Bronchial aspirate samples were assessed prior to platinum-based chemotherapy start in 39 patients with stage IIIb or IV NSCLC. K-ras mutations at codons 12 and...
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