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Article

Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer?

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2005

Camps Carlos, Sirera Rafael, Bremnes Roy, Blasco Ana, Sancho Eva, Bayo Pilar, Safont Maria Jose, Sánchez José Javier, Tarón Miquel, Rosell Rafael

Abstract excerpt

The purpose of this study was to investigate the prognostic significance of K-ras mutations in circulating DNA in advanced non-small lung cancer (NSCLC) patients. Serum samples were assessed prior to platinum-based chemotherapy start in 67 patients with advanced NSCLC (stage IIIB or IV), treated between April 1999 and June 2002. Patients were not previously treated with chemotherapy. K-ras oncogene mutations at...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
Codon
DNA, Neoplasm
Data Interpretation, Statistical
Female
Gene Amplification
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Lung Neoplasms

Male

Middle Aged

Point Mutation

Prognosis

Sensitivity and Specificity

Source

Identifiers

PMID: 16139926
DOI: 10.1016/j.lungcan.2005.06.007

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