Article
Predisposition to idiopathic thrombocytopenic purpura maps close to the major histocompatibility complex class I chain-related gene A.
Human immunology - 1 Mar 2009
Maia Maria Helena Thomaz, Peixoto Raquel de Lima, de Lima Clayton Pereira Silva, Magalhães Milena, Sena Leonardo, Costa Perpétua do Socorro Silva, Barbosa Fabíola Brasil, de Oliveira Layanna Freitas, Romero Matilde, Silva Christina Nogueira de Araujo, dos Santos Eduardo José Melo
Abstract excerpt
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune condition with poorly known etiology, characterized by platelet destruction. Genetic association studies of this disease are scarce, discrepant, and restricted to major histocompatibility complex (MHC) polymorphisms. Hence, a case-control study was conducted with an aim to map the MHC to IPT susceptibility using HLA-B and nine microsatellite loci...
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