Article
Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.
BMC nephrology - 17 Jul 2020
Bhatraju Pavan K, Cohen Max, Nagao Ryan J, Morrell Eric D, Kosamo Susanna, Chai Xin-Ya, Nance Robin, Dmyterko Victoria, Delaney Joseph, Christie Jason D, Liu Kathleen D, Mikacenic Carmen, Gharib Sina A, Liles W Conrad, Zheng Ying, Christiani David C, Himmelfarb Jonathan, Wurfel Mark M
Abstract excerpt
BACKGROUND: We previously identified two acute kidney injury (AKI) sub-phenotypes (AKI-SP1 and AKI-SP2) with different risk of poor clinical outcomes and response to vasopressor therapy. Plasma biomarkers of endothelial dysfunction (tumor necrosis factor receptor-1, angiopoietin-1 and 2) differentiated the AKI sub-phenotypes. However, it is unknown whether these biomarkers are simply markers or causal mediators...
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