Article
Reduction-sensitive and cysteine residue-mediated Streptococcus pneumoniae HrcA oligomerization in vitro.
Molecules and cells - 28 Feb 2009
Kwon Hyog-Young, Kim Eun-Hye, Tran Thao Dang Hien, Pyo Suhk-Neung, Rhee Dong-Kwon
Abstract excerpt
In both gram-positive and several gram-negative bacteria, the transcription of dnaK and groE operons is negatively regulated by HrcA; however, the mechanism modulating HrcA protein activity upon thermal stress remains elusive. Here, we demonstrate that HrcA is modulated via reduction and oligomerization in vitro. Native-PAGE analysis was used to reveal the oligomeric structure of HrcA. The oligomeric HrcA...
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