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Article

Genetic and physiologic analysis of the groE operon and role of the HrcA repressor in stress gene regulation and acid tolerance in Streptococcus mutans.

Journal of bacteriology - 1 Oct 2001

Lemos J A, Chen Y Y, Burne R A

Abstract excerpt

Our working hypothesis is that the major molecular chaperones DnaK and GroE play central roles in the ability of oral bacteria to cope with the rapid and frequent stresses encountered in oral biofilms, such as acidification and nutrient limitation. Previously, our laboratory partially characterized the dnaK operon of Streptococcus mutans (hrcA-grpE-dnaK) and demonstrated that dnaK is up-regulated in response to...

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Identifiers

PMID: 11567008
DOI: 10.1128/JB.183.20.6074-6084.2001
PMCID: PMC99687

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